Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia.

  title={Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia.},
  author={Masaki Nakayama and Kenji Uchimura and Ren-ying Zhu and Tomiko Nagayama and Marie E. Rose and Ruth Anne Stetler and Peter C. Isakson and Jiyuan Chen and Steven H Graham},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={95 18},
The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important mediator of inflammation, but it is not known whether COX2 activity is pathogenic in brain. To study the role of COX2 activity in ischemic injury in brain, expression of COX2 mRNA and protein and the effect of treatment with a COX2 inhibitor on neuronal survival in a rat model of global ischemia were determined. Expression of both COX2… CONTINUE READING
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