Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer.

@article{Tuynman2008Cyclooxygenase2II,
  title={Cyclooxygenase-2 inhibition inhibits c-Met kinase activity and Wnt activity in colon cancer.},
  author={Jurriaan Benjamin Tuynman and Louis Vermeulen and Elles M. J. Boon and Kristel Kemper and Aeilko H. Zwinderman and Maikel P Peppelenbosch and Dirk J Richel},
  journal={Cancer research},
  year={2008},
  volume={68 4},
  pages={
          1213-20
        }
}
Activity of receptor tyrosine kinases (RTK) in colorectal cancer (CRC) is associated with enhanced tumor growth and a poorer prognosis. In addition, cyclooxygenase-2 (COX-2) expression contributes to tumor growth and invasion. COX-2 inhibitors exhibit important anticarcinogenic potential against CRC, but the molecular mechanism underlying this effect and the relation with RTK signaling remain the subject of intense research effort. Therefore, the rapid effects of COX-2 inhibition in CRC on the… CONTINUE READING
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