Cyclooxygenase-2 inhibition improves antioxidative defense during experimental hypercholesterolemia.

Abstract

Scientific literature shows that inflammation and oxidative stress contribute in the pathogenesis of atherosclerosis. The oxidative stress is the consequence of an imbalance between the free radical generation and elimination. One source of free oxygen radicals is cyclooxygenase (COX)-2 and, therefore, inhibiting the activity of this enzyme is likely to… (More)

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