Cyclooxygenase-2 induction requires activation of nuclear factor of activated T-cells in Beas-2B cells after vanadium exposure and plays an anti-apoptotic role.

@article{Tang2007Cyclooxygenase2IR,
  title={Cyclooxygenase-2 induction requires activation of nuclear factor of activated T-cells in Beas-2B cells after vanadium exposure and plays an anti-apoptotic role.},
  author={Hao Tang and Yu Sun and Qingyu Xiu and Huiqi Lu and Huanxing Han},
  journal={Archives of biochemistry and biophysics},
  year={2007},
  volume={468 1},
  pages={92-9}
}
Vanadium, a potent toxic agent and carcinogen, is widely used in industry. Evidences show that exposure to vanadium is associated with an increased risk of lung cancer. But the mechanisms involved are far from fully understood. In this present study, we investigated that exposure of human bronchial epithelial cells (Beas-2B) to vanadium pentoxide resulted in an obvious induction of cyclooxygenase-2 (COX-2) expression and this induction was both dose- and time-dependent. Exposure of Beas-2B… CONTINUE READING