Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation.

@article{Adams1996Cyclooxygenase2II,
  title={Cyclooxygenase-2 induction in cerebral cortex: an intracellular response to synaptic excitation.},
  author={Judith M Adams and Y Collaço-Moraes and Jacqueline S de Belleroche},
  journal={Journal of neurochemistry},
  year={1996},
  volume={66 1},
  pages={6-13}
}
We have characterised the induction of the mitogen-inducible form of cyclooxygenase, COX-2, in the rat cerebral cortex in response to excitotoxin injection into the nucleus basalis. This model is associated with intense stimulation of the ascending pathway to the cerebral cortex, seizure activity, and subsequent ipsilateral cortical induction of various immediate early genes (IEGs), including c-fos, c-jun, and zif268, and ornithine decarboxylase enzyme activity and mRNA, all of which processes… CONTINUE READING

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