Cyclooxygenase-2 in newborn hyperoxic lung injury.

@article{Britt2013Cyclooxygenase2IN,
  title={Cyclooxygenase-2 in newborn hyperoxic lung injury.},
  author={Rodney D Britt and Markus Velten and Trent E Tipple and L D Nelin and Lynette K Rogers},
  journal={Free radical biology & medicine},
  year={2013},
  volume={61},
  pages={
          502-11
        }
}
Supraphysiological O2 concentrations, mechanical ventilation, and inflammation significantly contribute to the development of bronchopulmonary dysplasia (BPD).Exposure of newborn mice to hyperoxia causes inflammation and impaired alveolarization similar to that seen in infants with BPD.Previously, we demonstrated that pulmonary cyclooxygenase-2 (COX-2) protein expression is increased in hyperoxia-exposed newborn mice.The present studies were designed to define the role of COX-2 in newborn… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Similar Papers

Loading similar papers…