Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor-differentiated PC12 cells.

@article{McGinty2000Cyclooxygenase2EI,
  title={Cyclooxygenase-2 expression inhibits trophic withdrawal apoptosis in nerve growth factor-differentiated PC12 cells.},
  author={Ann McGinty and Yongsheng Chang and Andrey Sorokin and Dirk Bokemeyer and Michael J. Dunn},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 16},
  pages={12095-101}
}
Cyclooxygenase-2 (Cox-2), an enzyme responsible for catalyzing the committed step in prostanoid biosynthesis, is the product of an immediate early gene capable of being up-regulated by diverse stimuli. Significantly Cox-2 mRNA is absent from rat pheochromocytoma (PC12) cells, both basally and following stimulation with a range of agonists. Using PC12 cells… CONTINUE READING