Cyclooxygenase-2 expression in normal ovaries and epithelial ovarian neoplasms.

  title={Cyclooxygenase-2 expression in normal ovaries and epithelial ovarian neoplasms.},
  author={Yuri Matsumoto and Osamu Ishiko and Masashi Deguchi and Eri Nakagawa and Sachio Ogita},
  journal={International journal of molecular medicine},
  volume={8 1},
Cyclooxygenase-2 (COX-2) expression was investigated immunohistochemically in 57 epithelial ovarian neoplasms and in histologically normal ovaries. Positive immunostaining for COX-2 was observed in 78.6% (22/28) of the ovarian cancers and in 66.7% (14/21) of the borderline-malignant tumors. The rate of expression was significantly higher among the ovarian cancers than the benign cystadenomas (4/8; 50%) (p<0.05). There was a significant correlation between vascular endothelial growth factor… CONTINUE READING
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