Cyclooxygenase-2 expression in human pituitary tumors.

  title={Cyclooxygenase-2 expression in human pituitary tumors.},
  author={Sergio Vidal and K{\'a}lm{\'a}n Kov{\'a}cs and David C Bell and Eva Horv{\'a}th and Bernd Walter Scheithauer and Ricardo Vincent Lloyd},
  volume={97 11},
BACKGROUND Cyclooxygenase-2 (COX-2) plays a role in progression of colon, breast, pancreas, and lung carcinomas. The authors investigated COX-2 expression in pituitary tumors. METHODS Expression of COX-2 was evaluated in 164 surgically removed human pituitary tumors. Correlation of COX-2 with MIB-1, a cell proliferation marker, as well as angiogenesis, patient age, gender, tumor type, size, invasiveness, and metastatic potential was investigated. RESULTS Cyclooxygenase-2 immunoreactivity… CONTINUE READING