Cyclooxygenase-2 expression in human pancreatic adenocarcinomas.

@article{YipSchneider2000Cyclooxygenase2EI,
  title={Cyclooxygenase-2 expression in human pancreatic adenocarcinomas.},
  author={Michele T. Yip-Schneider and Darlene S Barnard and Steven D Billings and L O Cheng and Douglas K Heilman and Aifen Lin and Steven J Marshall and Pamela Crowell and Mark S. Marshall and Christopher J. Sweeney},
  journal={Carcinogenesis},
  year={2000},
  volume={21 2},
  pages={139-46}
}
Cyclooxygenase-2 (COX-2) expression is up-regulated in several types of human cancers and has also been directly linked to carcinogenesis. To investigate the role of COX-2 in pancreatic cancer, we evaluated COX-2 protein expression in primary human pancreatic adenocarcinomas (n = 23) and matched normal adjacent tissue (n = 11) by immunoblot analysis. COX-2 expression was found to be significantly elevated in the pancreatic tumor specimens compared with normal pancreatic tissue. To examine… CONTINUE READING

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