Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer.

  title={Cyclooxygenase-2 expression as a new marker for patients with colorectal cancer.},
  author={Takeyoshi Yamauchi and Masahiko Watanabe and Tetsuro Kubota and Hirotoshi Hasegawa and Yoshiyuki Ishii and Takashi Endo and Yasuo Kabeshima and Kyoko Yorozuya and Kentar{\^o} Yamamoto and Makio Mukai and Masaki Kitajima},
  journal={Diseases of the colon and rectum},
  volume={45 1},
PURPOSE Epidemiologic studies indicate that the use of nonsteroidal anti-inflammatory drugs, which inhibit cyclooxygenase activity, reduce the risk of colorectal cancer. In addition, several studies demonstrate increased expression of cyclooxygenase-2 in human colorectal cancer tissues. However, the role of cyclooxygenase-2 expression in colorectal cancer has not yet been fully established. The aim of this study was to clarify the clinicopathologic significance of cyclooxygenase-2 expression in… CONTINUE READING
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