Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors.

@article{Sales2001Cyclooxygenase2EA,
  title={Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors.},
  author={Kurt Jason Sales and Arieh Anthony Katz and Morghan Davis and Stefan Hinz and Roggert P. Soeters and Margaretha D. Hofmeyr and Robert Peter Millar and Henry N. Jabbour},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2001},
  volume={86 5},
  pages={2243-9}
}
The prevalence of cervical cancer in South African women is reported as being the highest in the world, occurring, on the average, in 60 of every 100,000 women. Cervical cancer is thus considered an important clinical problem in sub-Saharan AFRICA: Recent studies have suggested that epithelial tumors may be regulated by cyclooxygenase (COX) enzyme products. The purpose of this study was to determine whether cyclooxygenase-2 (COX-2) expression and PGE(2) synthesis are up-regulated in cervical… CONTINUE READING

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