Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro.

Abstract

Reduction of plasma low density lipoprotein (LDL) levels is associated with a reduced risk of myocardial infarction, stroke, and death. Some of this clinical benefit may be derived from an improvement in endothelium-dependent vasodilation. In the present study, we examined the effects of LDL reduction on cyclooxygenase (COX) activity and prostacyclin (PGI2… (More)

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@article{Smith2002Cyclooxygenase2dependentPF, title={Cyclooxygenase-2-dependent prostacyclin formation is regulated by low density lipoprotein cholesterol in vitro.}, author={Layton Harris Smith and Olivier Boutaud and Matthew D. Breyer and Jason D. Morrow and J Oates and Douglas E. Vaughan}, journal={Arteriosclerosis, thrombosis, and vascular biology}, year={2002}, volume={22 6}, pages={983-8} }