Cyclooxygenase-2-dependent neuronal death proceeds via superoxide anion generation.

  title={Cyclooxygenase-2-dependent neuronal death proceeds via superoxide anion generation.},
  author={Joo-Young Im and Doyeun Kim and Sang-Gi Paik and Pyung-Lim Han},
  journal={Free radical biology & medicine},
  volume={41 6},
Cyclooxygenase-2 (COX-2) expression is induced in the neurons of the pathologic brain and elevated COX-2 expressions can lead to neuronal death. Here, we report that COX-2 induction in cortical neurons induced by LPS pretreatment for more than 12 h increased the neurotoxic effects of low doses of Fe2+ by more than 2.5-fold. Moreover, the neurotoxicity induced by 30 muM Fe2+ in LPS-pretreated cells exceeded that induced by 100 microM Fe2+ in LPS-untreated cells. LPS pretreatment also similarly… CONTINUE READING
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