Cyclooxygenase-2-dependent and -independent effects of celecoxib in pancreatic cancer cell lines.

@article{ElRayes2004Cyclooxygenase2dependentA,
  title={Cyclooxygenase-2-dependent and -independent effects of celecoxib in pancreatic cancer cell lines.},
  author={Basil F. El-Rayes and Shadan Ali and Fazlul H. Sarkar and Philip Agop Philip},
  journal={Molecular cancer therapeutics},
  year={2004},
  volume={3 11},
  pages={1421-6}
}
Cyclooxygenase-2 (COX-2) is involved in inhibition of apoptosis, potentiation of cell growth, and angiogenesis and as such is a target for drug development. The COX-2 enzyme is frequently overexpressed in pancreatic cancer. The aim of this study was to determine the effects of celecoxib on the growth inhibition and induction of apoptosis by gemcitabine in pancreatic cancer cell lines. Baseline expression of COX-2 enzyme was determined by Western blot analysis in five human pancreatic cancer… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 29 references

Similar Papers

Loading similar papers…