Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.

Abstract

Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive thermogenesis. Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of beta-adrenergic… (More)
DOI: 10.1126/science.1186034

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