Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture.

@article{Hewett2000Cyclooxygenase2CT,
  title={Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture.},
  author={Sandra J. Hewett and Tracy F. Uliasz and Aniruddha S Vidwans and James A. Hewett},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={293 2},
  pages={417-25}
}
Cyclooxygenase isozymes (COX-1 and COX-2) are found to be constitutively expressed in brain, with neuronal expression of COX-2 being rapidly induced after numerous insults, including cerebral ischemia. Because overactivation of N-methyl-D-aspartate (NMDA) receptors has been implicated in the cell loss associated with ischemia, we characterized the expression of the COX isozymes in murine mixed cortical cell cultures and used isozyme-selective inhibitors to determine their relative contribution… CONTINUE READING
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