Cyclooxygenase-2 as a target for anticancer drug development.

  title={Cyclooxygenase-2 as a target for anticancer drug development.},
  author={Jean-Baptiste M{\'e}ric and Sylvie Rottey and Ken Andr{\'e} Olaussen and Jean-Charles Soria and David Khayat and Olivier Rixe and Jean-Philippe Spano},
  journal={Critical reviews in oncology/hematology},
  volume={59 1},
The two isoforms cyclooxygenase-1 and -2 catalyze the initial step in the formation of prostaglandins in a variety of pathophysiological processes. More recently their role in carcinogenesis has become more evident. They seem to influence apoptosis, angiogenesis, and invasion, and play a role in the production of carcinogens. Usually, a high level of COX-2 expression is found in cancer cells. However, low COX-2 expression is observed in some cancers like prostate or breast cancer. This… CONTINUE READING


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