Cyclooxygenase-2 as a potential target in the prevention and treatment of genitourinary tumors: a review.

@article{Pruthi2003Cyclooxygenase2AA,
  title={Cyclooxygenase-2 as a potential target in the prevention and treatment of genitourinary tumors: a review.},
  author={Raj Som Pruthi and Eric Derksen and Kris Gaston},
  journal={The Journal of urology},
  year={2003},
  volume={169 6},
  pages={2352-9}
}
PURPOSE Recent years have seen a dramatic expansion in our discovery and knowledge of the molecular mechanisms of cancer development and progression. The discovery and elucidation of prostaglandin pathways, in particular the molecular and clinical role of cyclooxygenase (COX)-2 function, has had important application to neoplasms. Current understanding of the role of COX-2 activity and, thereby, the potential clinical usefulness of COX-2 specific inhibitors as they apply to urological oncology… CONTINUE READING