Cyclooxygenase-2 and vascular endothelial growth factor expression in 5-fluorouracil-induced oral mucositis in hamsters: evaluation of two low-intensity laser protocols

@article{Lopes2009Cyclooxygenase2AV,
  title={Cyclooxygenase-2 and vascular endothelial growth factor expression in 5-fluorouracil-induced oral mucositis in hamsters: evaluation of two low-intensity laser protocols},
  author={N. Lopes and H. Plapler and M. C. Chavantes and R. Lalla and E. M. Yoshimura and M. T. S. Alves},
  journal={Supportive Care in Cancer},
  year={2009},
  volume={17},
  pages={1409-1415}
}
  • N. Lopes, H. Plapler, +3 authors M. T. S. Alves
  • Published 2009
  • Medicine
  • Supportive Care in Cancer
  • Goal of workThe aim of this study was to investigate the mechanisms whereby low-intensity laser therapy may affect the severity of oral mucositis.Materials and methodsA hamster cheek pouch model of oral mucositis was used with all animals receiving intraperitoneal 5-fluorouracil followed by surface irritation. Animals were randomly allocated into three groups and treated with a 35 mW laser, 100 mW laser, or no laser. Clinical severity of mucositis was assessed at four time-points by a blinded… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 42 REFERENCES
    Cyclooxygenases 1 and 2.
    • 2,615
    Updated clinical practice guidelines for the prevention and treatment of mucositis
    • 747
    • Open Access
    The pathobiology of mucositis
    • 607