Cyclooxygenase 2 and the kidney.

@article{Breyer2001Cyclooxygenase2A,
  title={Cyclooxygenase 2 and the kidney.},
  author={Matthew D Breyer and Raymond C Harris},
  journal={Current opinion in nephrology and hypertension},
  year={2001},
  volume={10 1},
  pages={
          89-98
        }
}
Cyclooxygenase metabolizes arachidonic acid to a family of bioactive fatty acids designated prostaglandins. Two isoforms of cyclooxygenase exist, designated COX1 and COX2. These isoforms are expressed in distinct but important areas of the kidney. COX1 predominates in vascular smooth muscle and collecting ducts, whereas COX2 predominates in the macula densa and nearby cells in the cortical thick ascending limb. COX2 is also highly expressed in medullary interstitial cells. Whereas COX1… CONTINUE READING
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