Cyclooxygenase-2 and prostaglandin F2 alpha in Syrian hamster Leydig cells: Inhibitory role on luteinizing hormone/human chorionic gonadotropin-stimulated testosterone production.

@article{Frungieri2006Cyclooxygenase2AP,
  title={Cyclooxygenase-2 and prostaglandin F2 alpha in Syrian hamster Leydig cells: Inhibitory role on luteinizing hormone/human chorionic gonadotropin-stimulated testosterone production.},
  author={M B Frungieri and Silvia In{\'e}s Gonz{\'a}lez-Calvar and Fernanda Parborell and Martin Albrecht and A Mayerhofer and Ricardo Sa{\'u}l Calandra},
  journal={Endocrinology},
  year={2006},
  volume={147 9},
  pages={4476-85}
}
We have previously found that cyclooxygenase-2 (COX-2), a key enzyme in the biosynthesis of prostaglandins (PGs), is present in the testicular interstitial cells of infertile men, whereas it is absent in human testes with no evident morphological changes or abnormalities. To find an animal model for further investigating COX-2 and its role in testicular steroidogenesis, we screened testes from adult species ranging from mice to monkeys. By using immunohistochemical assays, we found COX-2… CONTINUE READING