Cyclooxygenase-2 and its role in ovulation: a 2004 account.

  title={Cyclooxygenase-2 and its role in ovulation: a 2004 account.},
  author={J. Claude Sirois and Khampoune Sayasith and Kristy A. Brown and Angelika E Stock and Nadine Bouchard and Monique Dor{\'e}},
  journal={Human reproduction update},
  volume={10 5},
The pre-ovulatory surge of gonadotrophins triggers a marked and obligatory increase in follicular prostaglandin synthesis prior to ovulation, and the cyclooxygenase (COX) enzyme is a key rate-limiting step in the biosynthesis of prostaglandins. In the early 1990s, the pre-ovulatory rise in follicular prostaglandin synthesis was shown to result from the selective induction of a novel COX isoform, now referred to as COX-2. Differences in the time-course of COX-2 induction in species with a short… CONTINUE READING