Cyclooxygenase-2 Inhibition Improves Macrophage Function in Melanoma and Increases the Antineoplastic Activity of Interferon γ

@article{Duff2003Cyclooxygenase2II,
  title={Cyclooxygenase-2 Inhibition Improves Macrophage Function in Melanoma and Increases the Antineoplastic Activity of Interferon γ},
  author={Michael Duff and Philip P. Stapleton and Juan R. Mestre and Sirish Maddali and Gordon P. Smyth and Zhaoping Yan and Tracy A. Freeman and John M. Daly},
  journal={Annals of Surgical Oncology},
  year={2003},
  volume={10},
  pages={305-313}
}
AbstractBackground: Melanoma inhibits macrophage tumoricidal activity and increases the expression of cyclooxygenase-2 (COX-2). In this study, we sought to determine whether inhibition of COX-2 could restore macrophage function and hence maximize the antitumor activity of the immune stimulant interferon γ (IFNγ). Methods: Peritoneal macrophages were exposed to B16 melanoma-conditioned medium for 24 hours with or without the COX-2 inhibitor NS-398 and then were stimulated with… CONTINUE READING

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