Cyclooxygenase-2 Expression in Human Esophageal Carcinoma 1

  title={Cyclooxygenase-2 Expression in Human Esophageal Carcinoma 1},
  author={Katja C. Zimmermann and Mario Sarbia and A Weber and Franz Borchard and Helmut Erich Gabbert and Karsten Schr{\"o}},
On the basis of epidemiological observations that nonsteroidal antiinflammatory drugs reduce the risk of esophageal carcinoma, we studied the expression of cyclooxygenase-2 (COX-2) in esophageal squamous cell carcinomas (SCCs;n 5 172) and in esophageal adenocarcinomas (ADCs; n 5 27). Using immunohistochemistry, we observed COX-2 expression in 91% of the SCCs and in 78% of the ADCs. Western blot analysis showed enhanced expression of the COX-2 protein in some tumors as compared with normal… CONTINUE READING