Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma.

@article{Lakshmi2012Cyclooxygenase2765GCFP,
  title={Cyclooxygenase-2-765G>C functional promoter polymorphism and its association with oral squamous cell carcinoma.},
  author={A. Naga Lakshmi and Sadhnani Muralidhar and Chennaboina Kalyan Kumar and Addala Pavan Kumar and Pentapati Kalyana Chakravarthy and Vasala Anjaneyulu and Jamil Kaiser},
  journal={Journal of investigative and clinical dentistry},
  year={2012},
  volume={3 3},
  pages={182-8}
}
AIM Cyclooxygenase-2 is a key enzyme in the conversion of arachidonic acid to prostaglandins, and has critical role in the progression of several malignancies, including oral squamous cell carcinoma. METHODS We designed a case-control study to evaluate the susceptibility of the functional -765G>C genetic variation in oral squamous cell carcinoma patients. Polymerase chain reaction-based restriction fragment length polymorphism analysis was used to determine the polymorphism in oral squamous… CONTINUE READING
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