Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.

@article{Andersen2011Cyclooxygenase2P,
  title={Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.},
  author={Vibeke Andersen and Elaine E Nimmo and Henrik B Krarup and Hazel E. Drummond and Jane Christensen and Gwo-Tzer Ho and Mette Ostergaard and Anja Ernst and Charlie W. Lees and Bent Ascanius Jacobsen and Jack Satsangi and Ulla Vogel},
  journal={Inflammatory bowel diseases},
  year={2011},
  volume={17 4},
  pages={
          937-46
        }
}
BACKGROUND Inflammatory bowel diseases (IBDs) are a result of interactions between luminal pathogens and the intestinal immune response. Cyclooxygenase-2 (COX-2) plays a key role in the regulation of the inflammatory response upon stimulation by luminal pathogens via Toll-like receptors. METHODS Genotypes of the COX-2/PTGS2/PGHS2 A-1195G (rs689466), G-765C (rs20417), and T8473C (rs5275) polymorphisms were assessed in a Scottish and Danish case-control study including 732 Crohn's disease (CD… CONTINUE READING
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