Cyclooxygenase-2 (COX-2) and the kidney: current status and potential perspectives.

  title={Cyclooxygenase-2 (COX-2) and the kidney: current status and potential perspectives.},
  author={Andr{\'e} Schneider and Rolf A K Stahl},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={13 1},
Prostaglandins are important mediators of renal physiology and disease. The main enzyme which governs the synthesis of prostaglandins is cyclooxygenase (COX), also called prostaglandin endoperoxide synthase (PGS). Until recently it was assumed that only one cyclooxygenase gene and protein exists, an enzyme which is now called cyclooxygenase-l (COX-I) or the 'constitutive' isoform. Between 1989and 1991 however, several groups reported evidence for the existence of a mitogenand endotoxin… CONTINUE READING


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Prostaglandin G/H synthase (PGHS) inhibitors modulate glomerular MCP-1 mRNA expression in anti-Thy-I antiserum (ATS) induced glomerulonephritis (abstract)

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1 Excerpt

Cyclooxygenase-2 inhibition enhances glomerular mesangia1 cell proliferation in a rat model of renal ablation (abstract)

  • A Schneider, G Wolf, M Reszka, F Thaiss, U He1mchen, RAK. Stahl
  • Am Soc Nephrol1997;
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1 Excerpt

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