Cyclooxygenase-2–Dependent and Thromboxane-Dependent Vascular and Bronchial Responses are Regulated via p38 Mitogen-Activated Protein Kinase in Control and Endotoxin-Primed Rat Lungs

@article{Ermert2003Cyclooxygenase2DependentAT,
  title={Cyclooxygenase-2–Dependent and Thromboxane-Dependent Vascular and Bronchial Responses are Regulated via p38 Mitogen-Activated Protein Kinase in Control and Endotoxin-Primed Rat Lungs},
  author={Monika Ermert and Daniel Kuttner and Nils Eisenhardt and Christian Dierkes and Werner Seeger and Leander Ermert},
  journal={Laboratory Investigation},
  year={2003},
  volume={83},
  pages={333-347}
}
Mitogen-activated protein kinases (MAPKs) are part of an intracellular signaling machinery consisting of three known distinct pathways, each leading to activation of a different protein kinase: p38, ERK (extracellular signal-regulated kinase), or JNK (c-Jun N-terminal kinase). We investigated the role of the p38 MAPK pathway in the phenomenon of lung endotoxin “priming”: incubation of perfused rat lungs with lipopolysaccharide (LPS) for 2 hours results in drastically enhanced cyclooxygenase-2… Expand
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