Cyclooxygenase-2: a target for the prevention and treatment of breast cancer.

  title={Cyclooxygenase-2: a target for the prevention and treatment of breast cancer.},
  author={Louise R. Howe and Kotha Subbaramaiah and Adrienne M. Brown and Andrew J. Dannenberg},
  journal={Endocrine-related cancer},
  volume={8 2},
Cyclooxygenase-2 (COX-2), an inducible prostaglandin synthase, is normally expressed in parts of the kidney and brain. Aberrant COX-2 expression was first reported in colorectal carcinomas and adenomas, and has now been detected in various human cancers, including those of the breast. Strikingly, COX-2 overexpression in murine mammary gland is sufficient to cause tumour formation. To date, the role of COX-2 in tumorigenesis has been most intensively studied in the colon. Thus, the relationship… CONTINUE READING
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