Cyclooxygenase-1 gene knockout does not alter middle cerebral artery occlusion in a mouse stroke model.

@article{Cheung2002Cyclooxygenase1GK,
  title={Cyclooxygenase-1 gene knockout does not alter middle cerebral artery occlusion in a mouse stroke model.},
  author={Raymond Tak Fai Cheung and Zhong Pei and Zhe Feng and Liang yu Zou},
  journal={Neuroscience letters},
  year={2002},
  volume={330 1},
  pages={57-60}
}
Cyclooxygenase (COX) is crucial in inflammation; COX-1 is constitutional, and COX-2 is inducible. In this study, neurological function and infarct volume were evaluated at 24 h after permanent endovascular middle cerebral artery occlusion (MCAO) in both COX-1-gene knockout (homozygous or heterozygous) and wide-type mice. Similar infarct volumes and neurological deficits were seen among mice of different genotypes. There was no difference among the groups in arterial blood pressure and regional… CONTINUE READING
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