Cyclonatsudamine A, a new vasodilator cyclic peptide from Citrus natsudaidai.

@article{Morita2007CyclonatsudamineAA,
  title={Cyclonatsudamine A, a new vasodilator cyclic peptide from Citrus natsudaidai.},
  author={Hiroshi Morita and Maiko Enomoto and Yusuke Hirasawa and Toru Iizuka and Kazunori Ogawa and Nobuo Kawahara and Yukihiro Goda and Teruki Matsumoto and Koichi Takeya},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 19},
  pages={5410-3}
}
A new cyclic heptapeptide, cyclonatsudamine A (1), cyclo (-Gly-Tyr-Leu-Leu-Pro-Pro-Ser-), has been isolated from the peels of Citrus natsudaidai and the structure was elucidated by 2D NMR analysis and chemical degradation. Cyclonatsudamine A (1) relaxed norepinephrine-induced contractions of rat aorta, which may be mediated through the increased release of… CONTINUE READING