Cyclomaltoheptaose mixed esters of anti-inflammatory drugs and short-chain fatty acids and study of their enzymatic hydrolysis in vitro.

Abstract

In an effort to enhance the drug-loading capacity of cyclomaltoheptaose (beta-cyclodextrin, betaCD) and to combine the function of anti-inflammatory drugs with short-chain fatty acids (SCFA), ternary esters incorporating seven copies of an anti-inflammatory drug and 14 copies of a SCFA onto a beta-cyclodextrin core were designed and prepared. Acetic… (More)
DOI: 10.1016/j.carres.2008.10.001

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