Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity.

Abstract

Flaxseed (Linum usitatissimum seed) is widely used in food and natural health products. In our search for osteoclast differentiation inhibitors, some cyclic peptides isolated from flaxseed, known as the cyclolinopeptides, were discovered to have osteoclast differentiation inhibition activity. The osteoclast differentiation inhibition activity of cyclolinopeptides A-I (1-9) and their related derivatives (10-14) are described herein. Cyclolinopeptides F, H and I (6, 8 and 9), in particular, showed potent osteoclast differentiation inhibition activity.

DOI: 10.1016/j.bmcl.2016.02.040

Cite this paper

@article{Kaneda2016CyclolinopeptidesCP, title={Cyclolinopeptides, cyclic peptides from flaxseed with osteoclast differentiation inhibitory activity.}, author={Toshio Kaneda and Haruka Yoshida and Yuki Nakajima and Minako Toishi and Alfarius Eko Nugroho and Hiroshi Morita}, journal={Bioorganic & medicinal chemistry letters}, year={2016}, volume={26 7}, pages={1760-1} }