Cycloleucine (1-amino-cyclopentane carboxylic acid): Tubular reabsorption and inhibitory effect on amino acid transport in the rat kidney (microperfusion experiments)

@article{Silbernagl1975CycloleucineC,
  title={Cycloleucine (1-amino-cyclopentane carboxylic acid): Tubular reabsorption and inhibitory effect on amino acid transport in the rat kidney (microperfusion experiments)},
  author={Stefan Silbernagl},
  journal={Pfl{\"u}gers Archiv},
  year={1975},
  volume={353},
  pages={241-253}
}
Renal tubular reabsorption of cycloleucine (1-amino-cyclopentane carboxylic acid) was studiedin vivo et situ by continuous microperfusion of single proximal tubules of the rat. The results show: a) cycloleucine is reabsorbed rapidly compared with other amino acids b) this reabsorption is saturable and can be inhibited by oligomycin c) cycloleucine inhibits tubular reabsorption ofl-arginine, glycine, and ofl-phenylalanine. Mutual reciprocal inhibition occurs only withl-phenylalanine (and perhaps… CONTINUE READING

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