• Corpus ID: 38858485

Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro.

  title={Cyclohexylamino-demethoxy-hypocrellin B and photodynamic therapy decreases human cancer in vitro.},
  author={S. Xu and S. Chen and M. Zhang and Tao Shen and Z. Liu and Y. Zhao and Y. Wu},
  journal={Anti-cancer drug design},
  volume={16 6},
  • S. XuS. Chen Y. Wu
  • Published 1 December 2001
  • Chemistry
  • Anti-cancer drug design
2-Cyclohexylamino-2-demethoxy-hypocrellin B (CHAHB) is a new photosensitizer synthesized by the mild reaction between hypocrellin B (HB) and cyclohexylamine, in which the peri-hydroxylated perylenequinone structure of the parent HB is preserved and the photoresponse is enhanced markedly. Electron paramagnetic resonance (EPR) spin trapping measurements and 9,10-diphenylanthracene (DPA) bleaching studies were employed to investigate the photodynamic action of CHAHB in the presence of oxygen… 

Synthesis and Characterization of Three Novel Amphiphilic Aminated Hypocrellins as Photodynamic Therapeutic Agents¶

Three novel 2-amino-2-demethoxy-hypocrellins were synthesized by the mild reactions of hypocrellin B with 4-(2-Amino-ethyl)morpholine, N,N-dimethylethylenediamine and 1-aminos-ethylpiperazine, respectively, and showed strong absorption in the domain of the phototherapeutic window.

Optimization of hypocrellin B derivative amphiphilicity and biological activity

To satisfy the dual requirements of the fluent transportation in blood and the affinity to the target tissues of vascular diseases, hypocrellin derivatives with optimized amphiphilicity are expected.

Synthesis and Characterization of Three Novel Amphiphilic Aminated Hypocrellins as Photodynamic Therapeutic Agents ¶

To improve the amphiphilicities and red absorption of the hypocrellins, three novel 2‐amino‐2‐demethoxy‐hypocrellins were synthesized by the mild reactions of hypocrellin B with

Novel phototherapeutic agents: Investigation and progress of hypocrellin derivatives

The designed and synthesized amphiphilic aminated hypocrellin derivatives possess the highest photodynamic activity and the water solubility and the experiments in vitro and in vivo on the derivatives are under way at present.

Drug-delivery and multifunction possibilities of hypocrellin photosensitizers

Further studies on quantitative recognition of various biomolecules at a cellular level, may find a new clue to treat tumors by joint usage of photodynamic diagnosis (PDD) and PDT.

Novel Surfactant‐like Hypocrellin Derivatives to Achieve Simultaneous Drug Delivery in Blood Plasma and Cell Uptake

Water‐soluble derivatives of hypocrellins can be safely delivered in blood plasma but lose their photodynamic activity in vivo due to poor cell uptake, while hydrophobic derivatives retaining their

Isolation and evaluation of endophytic fungi with antimicrobial ability from Phyllostachys edulis

This study is the first report on the antimicrobial activity of endophytic fungi associated with branches of Ph. edulis, found to have high bioactivity against the frequent plant pathogenic fungus Botryotinia fuckeliana, and two of the isolates also inhibited the growth of phytopathogen Thanatephorus cucumeris noteworthily.

A novel elsinochrome A derivative: a study of drug delivery and photodynamic activity.

  • Yang ZhangJie Xie Jing-quan Zhao
  • Chemistry, Biology
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
  • 2009
5-(3-mercapto-1-propanesulfonic acid)-substituted elsinochrome A with an amphiphilicity was designed and synthesized by considering drug delivery and biological activity requirements and confirmed that the photodynamic activity of MPEA was as high as 60% of that of its parent EA, which is significantly higher than that of most other photosensitizers.