Cycloheximide Inhibits Actin Cytoskeletal Dynamics by Suppressing Signaling via RhoA.

Abstract

Genome-wide screening of the yeast Saccharomyces cerevisiae knockout collection was used to characterize chemical-genetic interactions of cycloheximide (CHX). The results showed that while the act1Δ mutant was the only deletion mutant in the heterozygous essential gene deletion collection that showed hypersensitivity to sub-inhibitory concentrations of CHX… (More)
DOI: 10.1002/jcb.25601

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