Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions.

@article{Shu2007CyclodextrinsSN,
  title={Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions.},
  author={H-J Shu and C-M Zeng and C Wang and Douglas F Covey and Charles F Zorumski and Steven J Mennerick},
  journal={British journal of pharmacology},
  year={2007},
  volume={150 2},
  pages={164-75}
}
BACKGROUND AND PURPOSE Neuroactive steroids are potent modulators of GABA(A) receptors and are thus of interest for their sedative, anxiolytic, anticonvulsant and anaesthetic properties. Cyclodextrins may be useful tools to manipulate neuroactive effects of steroids on GABA(A) receptors because cyclodextrins form inclusion complexes with at least some steroids that are active at the GABA(A) receptor, such as (3alpha,5alpha)-3-hydroxypregnan-20-one (3alpha5alphaP, allopregnanolone… CONTINUE READING

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