Cyclodextrins--enabling excipients: their present and future use in pharmaceuticals.

  title={Cyclodextrins--enabling excipients: their present and future use in pharmaceuticals.},
  author={Diane O. Thompson},
  journal={Critical reviews in therapeutic drug carrier systems},
  volume={14 1},
Cyclodextrins (CDs) complex hydrophobic drugs, increasing their aqueous solubility and stability. CD complexation enables the creation of formulations for water-insoluble drugs that are difficult to deliver with more traditional formulations. Currently, 10 pharmaceutical products are marketed as CD formulations. A CD-based formulation, like any other, is evaluated for quality and safety. The 6 CDs currently available for use in pharmaceutical products are alpha-, beta-, and gamma-CD and the… CONTINUE READING

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