Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: formation of aggregates and higher-order complexes.

@article{Duan2005CyclodextrinSO,
  title={Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: formation of aggregates and higher-order complexes.},
  author={Matt Duan and Nelson Zhao and Ina B Ossurard{\'o}ttir and Thorsteinn Thorsteinsson and Thorsteinn Loftsson},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={297 1-2},
  pages={
          213-22
        }
}
It is well known that water-soluble cyclodextrins form inclusion complexes with many lipophilic water-insoluble drugs and that such complexation frequently enhances the aqueous solubility of drugs. It is also well known that various excipients, such as water-soluble polymers, organic acids and bases and metal ions can enhance the solubilizing effects of cyclodextrins. However, it is not clear how these excipients enhance the effects. The effects of cyclodextrins, 2-hydroxypropyl-beta… 
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Previous studies have indicated that conventional description of drug/cyclodextrin complexes in aqueous solutions as inclusion complexes are not as unambiguous as one might think. It has been shown
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TLDR
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NMR spectroscopic studies clearly indicated that alpha-CyD with the small cavity includes the methoxyethylbenzene moiety of Met molecule shallowly in the cavity, depositing the benzene and the meth Oxy moieties around the secondary and primary sides, respectively, of the cavity.
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