Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: formation of aggregates and higher-order complexes.

@article{Duan2005CyclodextrinSO,
  title={Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: formation of aggregates and higher-order complexes.},
  author={Matt Duan and Nelson Zhao and Ina B Ossurard{\'o}ttir and Thorsteinn Thorsteinsson and Thorsteinn Loftsson},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={297 1-2},
  pages={
          213-22
        }
}
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References

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The natural β-cyclodextrin (βCD) and its complexes have limited solubility in aqueous solutions. This low aqueous solubility, as well as low aqueous solubility of the guest molecule (i.e. triclosan…
The effects of organic salts on the cyclodextrin solubilization of drugs.
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TLDR
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TLDR
It was found that in toothpastes, natural beta-cyclodextrin (betaCD) was just as good a solubilizer as the more water-soluble betaCD derivatives, which resulted in an almost 3-fold enhancement of triclosan availability compared to an identical toothpaste containing no cyclodesxtrin.
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TLDR
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TLDR
NMR spectroscopic studies clearly indicated that alpha-CyD with the small cavity includes the methoxyethylbenzene moiety of Met molecule shallowly in the cavity, depositing the benzene and the meth Oxy moieties around the secondary and primary sides, respectively, of the cavity.
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