Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: formation of aggregates and higher-order complexes.

@article{Duan2005CyclodextrinSO,
  title={Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: formation of aggregates and higher-order complexes.},
  author={Matt Duan and Nelson Zhao and Ina B Ossurard{\'o}ttir and Thorsteinn Thorsteinsson and Thorsteinn Loftsson},
  journal={International journal of pharmaceutics},
  year={2005},
  volume={297 1-2},
  pages={
          213-22
        }
}
Analysis of triclosan inclusion complexes with β-cyclodextrin and its water-soluble polymeric derivative.
Cyclodextrin solubilization of celecoxib: solid and solution state characterization
The low aqueous solubility of celecoxib (CCB) hampers its oral bioavailability and permeation from aqueous environment through biological membranes. The aim of this study was to enhance the aqueous
The complexation efficiency
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Determination of CE is a simple method for quick evaluating the solubilizing effects of different cyclodextrins and/or the effects of excipients on thesolubilization and the influence of the intrinsic solubility and drug lipophilicity on the CE.
Effect of self-aggregation of γ-cyclodextrin on drug solubilization
The purpose of this study was to investigate the physicochemical properties of drug-saturated aqueous cyclodextrin (CD) solutions. Phase solubility profiles of different drugs were determined in
Self-assembly of cyclodextrins: the effect of the guest molecule.
THE CYCLODEXTRINS: A REVIEW
TLDR
The purp review is to discuss and summarize some of the findings and applications of cyclodextrin (CD) and their derivatives in different areas of drug delivery, which focuses on its use for parenteral, oral, ophthalmic and nasal drug delivery.
Studies of curcumin and curcuminoids. XXXVI. The stoichiometry and complexation constants of cyclodextrin complexes as determined by the phase-solubility method and UV–Vis titration
Cyclodextrin (CD) complex stoichiometry and complexation constant with two symmetric curcuminoids and two unsymmetric curcuminoid-like compounds were investigated and compared by two independent
“A Short Review on Cyclodextrin Inclusion Complexes: Synthesis, Characterization and Their Applications”
TLDR
The reported behavior of inclusion complexes had been used to improve the aqueous solubility, bioavailability, stability of unstable drugs, reduction of the unwanted side effects and smell or bad taste can also be masked of a drug molecule.
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References

SHOWING 1-10 OF 22 REFERENCES
Cyclodextrin Solubilization of the Antibacterial Agents Triclosan and Triclocarban: Effect of Ionization and Polymers
The natural β-cyclodextrin (βCD) and its complexes have limited solubility in aqueous solutions. This low aqueous solubility, as well as low aqueous solubility of the guest molecule (i.e. triclosan
Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization.
TLDR
The effects of substitution on various cyclodextrins properties and the forces involved in the drug-cyclodextrin complex formation are discussed, and methods which are useful in the optimization of complexation efficacy are reviewed.
Self-association and cyclodextrin solubilization of drugs.
TLDR
The results indicate that drug/cyclodextrin complexes can self-associate to form water-soluble aggregates, which then can further solubilize the drug through non-inclusion complexation.
Self Association and Cyclodextrin Solubilization of NSAIDs
The phase solubility profiles with HPβCD of thesodium salt of the NSAIDs(non-steriodal anti-inflammatory drugs) ibuprofen anddiflunisal were studied. Theslopes of the phase solubility diagrams were
Effect of cyclodextrins and polymers on triclosan availability and substantivity in toothpastes in vivo.
TLDR
It was found that in toothpastes, natural beta-cyclodextrin (betaCD) was just as good a solubilizer as the more water-soluble betaCD derivatives, which resulted in an almost 3-fold enhancement of triclosan availability compared to an identical toothpaste containing no cyclodesxtrin.
Self-association of cyclodextrins and cyclodextrin complexes.
TLDR
There is a growing body of evidence that supports the important contribution of non-inclusion-based aspects for drug solubilization by cyclodextrins including surfactant-like effects and molecular aggregation.
NMR spectroscopic characterization of metoprolol/cyclodextrin complexes in aqueous solution: cavity size dependency.
TLDR
NMR spectroscopic studies clearly indicated that alpha-CyD with the small cavity includes the methoxyethylbenzene moiety of Met molecule shallowly in the cavity, depositing the benzene and the meth Oxy moieties around the secondary and primary sides, respectively, of the cavity.
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