Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: formation of aggregates and higher-order complexes.
@article{Duan2005CyclodextrinSO, title={Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: formation of aggregates and higher-order complexes.}, author={Matt Duan and Nelson Zhao and Ina B Ossurard{\'o}ttir and Thorsteinn Thorsteinsson and Thorsteinn Loftsson}, journal={International journal of pharmaceutics}, year={2005}, volume={297 1-2}, pages={ 213-22 } }
73 Citations
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References
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Cyclodextrin Solubilization of the Antibacterial Agents Triclosan and Triclocarban: Effect of Ionization and Polymers
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The natural β-cyclodextrin (βCD) and its complexes have limited solubility in aqueous solutions. This low aqueous solubility, as well as low aqueous solubility of the guest molecule (i.e. triclosan…
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The phase solubility profiles with HPβCD of thesodium salt of the NSAIDs(non-steriodal anti-inflammatory drugs) ibuprofen anddiflunisal were studied. Theslopes of the phase solubility diagrams were…
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NMR spectroscopic studies clearly indicated that alpha-CyD with the small cavity includes the methoxyethylbenzene moiety of Met molecule shallowly in the cavity, depositing the benzene and the meth Oxy moieties around the secondary and primary sides, respectively, of the cavity.