Cyclodextrin-containing polymer delivery system for light-directed siRNA gene silencing.

Abstract

In this study, we have investigated the possibility of combining a cyclodextrin-containing polymer (CDP) with siRNA molecules to modulate gene expression in a light-directed manner through photochemical internalization (PCI) technology. We utilized S100A4 as a model gene to evaluate the efficacy of gene silencing. After optimization of carrier/cargo ratio… (More)
DOI: 10.1089/oli.2010.0230

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