Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency.

@article{Kurosawa2012CyclocreatineTI,
  title={Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency.},
  author={Y. Kurosawa and T. Degrauw and D. Lindquist and V. Blanco and G. Pyne-Geithman and T. Daikoku and J. B. Chambers and S. Benoit and J. Clark},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 8},
  pages={
          2837-46
        }
}
The second-largest cause of X-linked mental retardation is a deficiency in creatine transporter (CRT; encoded by SLC6A8), which leads to speech and language disorders with severe cognitive impairment. This syndrome, caused by the absence of creatine in the brain, is currently untreatable because CRT is required for creatine entry into brain cells. Here, we developed a brain-specific Slc6a8 knockout mouse (Slc6a8-/y) as an animal model of human CRT deficiency in order to explore potential… Expand
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