Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation.

  title={Cyclobutane pyrimidine dimers are predominant DNA lesions in whole human skin exposed to UVA radiation.},
  author={St{\'e}phane Mouret and Caroline Baudouin and Marie Charv{\'e}ron and Alain Favier and Jean Cadet and Thierry Douki},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 37},
Solar UV radiation is the most important environmental factor involved in the pathogenesis of skin cancers. The well known genotoxic properties of UVB radiation (290-320 nm) mostly involve bipyrimidine DNA photoproducts. In contrast, the contribution of more-abundant UVA radiation (320-400 nm) that are not directly absorbed by DNA remains poorly understood in skin. Using a highly accurate and quantitative assay based on HPLC coupled with tandem mass spectrometry, we determined the type and the… CONTINUE READING


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