Cyclobutane-Type Pyrimidine Dimers in Polynucleotides

@article{Setlow1966CyclobutaneTypePD,
  title={Cyclobutane-Type Pyrimidine Dimers in Polynucleotides},
  author={Richard B. Setlow},
  journal={Science},
  year={1966},
  volume={153},
  pages={379 - 386}
}
  • R. Setlow
  • Published 22 July 1966
  • Chemistry, Biology
  • Science
The formation of cyclobutane-type dimers between adjacent pyrimidine residues in model polynucleotides or DNA may be represented by the general scheme See pdf 379.pdf Whereas the formation of all other known photoproducts follows the irreversible path See pdf 379.pdf Thus dimers are distinguished from other photoproducts by the fact that they can be monomerized, as well as formed, by ultraviolet irradiation. At large incident fluxes of photons the steady-state value of dimers depends on… 
Formation and Destruction of Pyrimidine Dimers in Polynucleotides by Ultra-violet Irradiation in the Presence of Proflavine
TLDR
Although Beukers was unable to show that the destruction of the dimers in DNA consists of a simple reversion to monomers, he suggested that this might be demonstrated by means of experiments with organized polymer dI.dC consisting of strands ofpolydeoxyinosinic acid and polydeoxycytidylic acid, which has already been used to show the enzymatic destruction of uracil dimers by photoreactivating enzyme in the presence of visible light.
PHOTOCHEMISTRY AND PHOTOBIOLOGY OF SPORE-FORMING BACTERIA
TLDR
The pyrimidine base,thymine, could form dimers when irradiated with ultraviolet light (UV) either in frozen solution or when the thymine had been incorporated into the DNA of living cells, and these dimers caused 50 to 90% of the lethal effect of UV in viruses and bacteria.
PHOTOPHYSICS AND PHOTOCHEMISTRY OF PHOTOREACTIVATION
TLDR
The known ability of PRE to monomerize dimers of thymine, cytosine and uracil suggests that the carbonyl groups at 2 position of the pyrimidine ring may be important in the interaction between enzyme and dimer.
SUBSTRATE DEPENDENCE OF THE ACTION SPECTRUM FOR PHOTOENZYMATIC REPAIR OF DNA
TLDR
The results mean that the action spectrum is not simply the absorption spectrum of a chromophore carried by the photoreactivating enzyme, nor is it solely determined by the nature of the substrate photoproduct, but is at least partly determinedBy the over‐all polynueleotide structure.
The photochemistry, photobiology, and repair of polynucleotides.
  • R. Setlow
  • Biology
    Progress in nucleic acid research and molecular biology
  • 1968
Computational reference data for the photochemistry of cyclobutane pyrimidine dimers.
  • M. Barbatti
  • Chemistry
    Chemphyschem : a European journal of chemical physics and physical chemistry
  • 2014
TLDR
Diverse high-level quantum-chemical methods were used to determine the spectroscopic properties of neutral and charged species of thymine dimers, and a new stable dimer with methylmethylidene-hexahydropyrimidine structure was found in the S0 state.
Physical and Environmental Factors Influencing the Photochemistry of DNA
TLDR
Thymine dimers showed that such dimers inhibit the synthesis of DNA in growing bacteria, and several review articles are available, discussing the photochemistry of DNA and the nature and biological significance of pyrimidine dimers.
24 Photoreactivating Enzymes
Photoreactivation of herpes simplex virus in human fibroblasts
TLDR
It is shown that human photoreactivating enzyme in fibroblasts can restore infectivity to ultraviolet-irradiated herpes simplex virus (HSV) and monomerise dimers in DNA.
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