Cyclobarbital as a test substance for oxidative drug metabolism in man. Findings in neuropsychiatric patients

@article{BreyerPfaff2004CyclobarbitalAA,
  title={Cyclobarbital as a test substance for oxidative drug metabolism in man. Findings in neuropsychiatric patients},
  author={U. Breyer-Pfaff and H. Jerg and F. Petruch},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={15},
  pages={433-441}
}
SummaryThe disappearance of cyclobarbital from plasma has been followed in healthy volunteers and in neurological and psychiatric patients after oral administration of one tablet of Phanodorm®, containing cyclobarbital calcium 200 mg. Plasma levels were measured by a thin-layer chromatographic method with in situ densitometry. The average t1/2 in healthy female and male volunteers was 13.3 h, and with the assumption of complete availability a mean distribution coefficient of 0.69 l/kg−1 and a… Expand
1 Citations
Assessment of drug metabolism in hepatic disease: Comparison of plasma kinetics of oral cyclobarbital and the intravenous aminopyrine breath test
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The cyclobarbital (CB) half-life was prolonged and the clearance reduced in patients with viral hepatitis, cirrhosis, or alcoholic liver damage as compared to data from 17 control subjects and discrimination between patients with and without disordered liver function was similar in the two drug elimination tests. Expand

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