Cyclo-oxygenase inhibition reduces tumour growth and metastasis in an orthotopic model of breast cancer

@article{Connolly2002CyclooxygenaseIR,
  title={Cyclo-oxygenase inhibition reduces tumour growth and metastasis in an orthotopic model of breast cancer},
  author={Elizabeth M. Connolly and Judith H. Harmey and Thomas O'grady and Deidre A Foley and Graham Roche-Nagle and Elaine W. Kay and M. Arumugasamy},
  journal={British Journal of Cancer},
  year={2002},
  volume={87},
  pages={231 - 237}
}
The effect of selective and non-selective cyclo-oxygenase inhibition on tumour growth and metastasis in an orthotopic model of breast cancer was investigated. 4T1 mammary adenocarcinoma cells were injected into the mammary fat pad of female BALB/c mice. When tumours reached a mean tumour diameter of 8.4±0.4 mm, mice were randomised into three groups (n=6 per group) and received daily intraperitoneal injections of the selective cyclo-oxygenase-2 inhibitor, SC-236, the non selective cyclo… CONTINUE READING
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