Cyclo-oxygenase-2 mediated prostaglandin release regulates blood flow in connective tissue during mechanical loading in humans.

@article{Langberg2003Cyclooxygenase2MP,
  title={Cyclo-oxygenase-2 mediated prostaglandin release regulates blood flow in connective tissue during mechanical loading in humans.},
  author={Henning Langberg and R Boushel and Dorthe Skovgaard and Niels Risum and Michael Kjaer},
  journal={The Journal of physiology},
  year={2003},
  volume={551 Pt 2},
  pages={683-9}
}
Mechanical loading is known to increase connective tissue blood flow of human tendons and to cause local release of vasodilatory substances. The present study investigated the importance of prostaglandins (PG) formed by cyclo-oxygenase isoforms (COX-1 and 2) for the exercise-related increase in blood flow in connective tissue. Healthy individuals (n = 24, age: 23-31 years) underwent 30 min of intermittent, isometric, plantarflexion with both calf muscles either without (n = 6, Control, C) or… CONTINUE READING

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