Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer.

@article{Costa2002Cyclooxygenase2E,
  title={Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer.},
  author={C Costa and Raquel Soares and Jorge S Reis-Filho and Dina Raquel Aguilera Leit{\~a}o and Isabel Amendoeira and F Schmitt},
  journal={Journal of clinical pathology},
  year={2002},
  volume={55 6},
  pages={429-34}
}
AIMS Cyclo-oxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin biosynthesis. COX-2 is induced by a wide variety of stimuli, and present during inflammation. COX-2 overexpression has been observed in colon, head and neck, lung, prostate, stomach, and breast cancer. In colon and gastric cancer, COX-2 expression was associated with angiogenesis. The aim of this study was to determine the relation between COX-2 expression and angiogenesis in breast cancer, and to correlate the… CONTINUE READING