Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension.

@article{Adeagbo2005Cyclooxygenase2EA,
  title={Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension.},
  author={Ayotunde S. O. Adeagbo and Xiaodong Zhang and Darshana P. Patel and Irving G. Joshua and Yang Wang and Xichun Sun and Immaculata N Igbo and M Oriowo},
  journal={Journal of hypertension},
  year={2005},
  volume={23 5},
  pages={1025-36}
}
OBJECTIVE To test the hypothesis that the enhanced vascular responsiveness to norepinephrine that occurs during deoxycorticosterone acetate (DOCA)-salt induced hypertension is causally related to increased expression of cyclo-oxygenase (COX)-2 and oxidative stress, which diminishes the vasomodulatory influence of endothelium-derived nitric oxide. METHODS Four groups of age-matched, male Sprague-Dawley rats were studied: Sham (normotensive); DOCA-salt (hypertensive); DOCA-salt treated with… CONTINUE READING

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