Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing.

  title={Cyclo-oxygenase-1 and -2 contribution to endothelial dysfunction in ageing.},
  author={Christophe Heymes and A{\"i}da Habib and Dang Yang and Eric Mathieu and Françoise Marotte and J Samuel and Chantal M Boulanger},
  journal={British journal of pharmacology},
  volume={131 4},
Experiments were designed to investigate the role of cyclo-oxygenase isoforms in endothelial dysfunction in ageing. Aortic rings with endothelium of aged and young (24 vs 4 month-old) Wistar rats, were mounted in organ chambers for the recording of changes in isometric tension. In young rats, acetylcholine (ACh) caused a complete relaxation which was not affected by indomethacin (0.3 microM), NS-398 (a preferential COX-2 inhibitor; 1 microM), SQ-29548 (a thromboxane-receptor antagonist; 1… CONTINUE READING
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